The roles of personality and genetics in smoking behavior

Both genes and personality traits have been implicated in cigarette smoking. This study examined the role of a dopamine transporter gene polymorphism (SLC6A3-9) and of the personality trait of Novelty Seeking in the smoking behavior of a population of 124 current, former and non-smokers. Individuals with SLC6A3-9 were more likely to have been able to quit smoking than were individuals without this allele. In addition, using the Temperament and Character Inventory (TCI) as a measure of personality, a low score in Novelty Seeking was associated with allele 9. These results could have future significance for the design of smoking cessation programs.