Synthesis of dimethylthiolated imines as precursors for 1,2,3-vicinal tricarbonyl compounds via a beta-lactam ring

The resistance of disease-causing microorganisms to formerly effective medications is on the rise. At the forefront of this issue is the resistance of infection-causing bacteria to commonly prescribed antibiotics. The inefficacy of the affordable, relatively safe antibiotics formerly favored by physicians has led to both economic and public health related problems. In this Thesis, I describe the synthesis of six dimethylthiolated imines. These imines will be used to make 1,2,3-vicinal tricarbonyl compounds with a breadth of synthetic versatility, including potential as candidates for serine protease inhibition.