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SYNTHESIS AND APPLICATION OF FLUORESCENTLY LABELED MONOCYCLIC THIO-ß-LACTAM DERIVITIVES

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posted on 2023-09-07, 02:01 authored by Victor Leatherman Schultz

Novel methodologies for the synthesis of fluorescently labeled monobactam derivatives were developed and explored. Two separate ß-lactam derivatives, 4-(4 aminophenylthio)azetidin-2-one and 4-phenylsulflanyl-azetidin-2-one were labeled with several combinations of fluorophores and electron withdrawing groups allowing for these drugs to be observed within a living bacterial cell. Observation of the drugs in vivo will provide valuable information as to the structure activity relationship and exact mechanism of action of these compounds.

History

Publisher

ProQuest

Notes

Degree awarded: M.S. Chemistry. American University

Handle

http://hdl.handle.net/1961/11108

Degree grantor

American University. Department of Chemistry

Degree level

  • Masters

Submission ID

10038

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