SEX DIFFERENCES IN 3,4-METHYLENEDIOXYPYROVALERONE (MDPV)-INDUCED TASTE AVOIDANCE AND PLACE PREFERENCES

Rationale. Synthetic cathinones, otherwise known as “bath salts”, have gained significant attention in the last few years as a result of increased use and abuse. One such compound, 3,4-methylenedioxypyrovalerone (MDPV), is structurally and behaviorally similar to cocaine and has been shown to possess both aversive and rewarding effects. For a host of other drugs, each of these effects (and their relative balance) can be influenced by a variety of factors, including sex, which in turn impacts drug taking behavior. In this context, the present assessment sought to determine whether males and females differed in MDPV-induced CTA and CPP. Methods. Both male and female Sprague-Dawley rats underwent a combined CTA/CPP procedure, in which an injection of one of three doses of MDPV (1.0, 1.8 or 3.2 mg/kg) was paired with both a novel saccharin solution and a novel environment and changes in preferences for these stimuli were examined.Results. Dose-dependent taste avoidance was evident in both sexes, although this avoidance was attenuated in females compared to males. MDPV also produced dose-dependent place preferences in all drug-treated animals, but these preferences did not vary as a function of sex. Conclusions. The fact that females showed an attenuated MDPV-induced taste avoidance response compared to males (despite comparable MDPV-induced place preferences) suggests that females may have a heightened susceptibility to use and abuse of MDPV, paralleling results seen with cocaine and other stimulants. The present findings extend the behavioral characterization of MDPV and the factors that may alter its aversive and rewarding effects.