Reactions of cerium(IV) ammonium nitrate (CAN) with dithiodimethyl beta-lactam sulfides and sulfones: New synthetic approach to 1,3-dicarbonyl systems

For many years, beta-lactam antibiotics have been used for the treatment of bacterial infections including Staphylococcus aureus infections. However, the efficacy of some of these beta-lactam drugs is slowly decreasing because of the evolution of drug-resistance microorganisms. One of the ways bacteria grow resistance is by the production of beta-lactamases. Therefore, one of the focuses to improve these beta-lactam antibiotics includes the design of beta-lactamase inhibitors that block the enzymes and strengthen the efficacy of the drugs. In this project, the main focus was on the synthesis of novel monocyclic beta-lactams containing either dithiodimethylated group or disulfoxydimethylated group at the C-4 position, along with their chemical properties and their reactions with Cerium (IV) Ammonium Nitrate (CAN).