Immune responses to Campylobacter jejuni in mice

<p>Proliferative responses of lymphocytes taken from Peyer's patches and spleens of mice orally infected with Campylobacter jejuni were tested against sonicated whole organisms. Peyer's patch lymphocytes from mice given a single dose of organisms proliferated specifically to C. jejuni sonicates, but not to sonicates of Campylobacter fetus, a closely related organism. Splenic lymphocytes from mice that received a single immunization did not proliferate. In contrast, splenic lymphocytes from mice immunized at two week intervals over a period of several months, were able to proliferate but Peyer's patch lymphocytes from such boosted mice did not proliferate. These results suggest that after multiple infections proliferating T cells recirculated from the Peyer's patches to more distant organs.</p>