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Design and synthesis of triple action NO-containing beta-lactams

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posted on 2023-08-04, 21:04 authored by Yukiyo Ikeda

Since the discovery of penicillin, the development of antibiotics has been one of the major fields of medicine. Especially, bacterial resistance toward drugs is a global problem. Therefore, it is a great importance to design and synthesize new antimicrobial drugs. Production of beta-lactamases is one of the main causes of bacterial resistance. To prevent the bacterial resistance caused by beta-lactamases, beta-lactams, having the potential to act as beta-lactamase inhibitor, has been developed. This project focused on the design and synthesis NO containing beta-lactam, which perform as triple function inhibitors. The triple function is designed not only for inhibiting beta-lactamases, but also for releasing a nitric oxide, which is a toxin because it is expected to bind to the target enzyme. In the synthesis of these beta-lactams, microwave irradiation was used, which resulted in a high yield of imine. This resulted in obtaining clean beta-lactams in a very good yield.

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ProQuest Dissertations & Theses

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English

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Thesis (M.S.)--American University, 2004.

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http://hdl.handle.net/1961/thesesdissertations:5704

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application/pdf

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