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Adipocytes, Obesity and Multiple Myeloma

thesis
posted on 2023-08-04, 17:04 authored by Gervaise H. Henry

Multiple myeloma, a hematological malignancy characterized by monoclonal plasma cells in the bone marrow, affects nearly 23,000 Americans per year. Obesity contributes to the development and progression of multiple myeloma, yet the relationship between multiple myeloma cells and adipocytes found in the tumor microenvironment has not been fully elucidated. To examine how adipocytes contribute to the growth and progression of the cancer, human multiple myeloma cell lines were cocultured with primary human adipocytes isolated from lipoaspirates. We found that multiple myeloma cells grown with adipocytes showed increased viability, angiogenic potential, and invasion. Moreover adipocytes from individuals with increased body mass index further compounded this. It was also shown that the multiple myeloma cells alter the adipocytes' protein expression to further exasperate this. Thus, we demonstrate an important role for adipocytes in promoting myeloma pathologies.

History

Publisher

ProQuest

Language

English

Handle

http://hdl.handle.net/1961/16815

Committee chair

Kathleen L. DeCicco-Skinner

Committee member(s)

Colin J. Saldanha; Anna M. Bentley

Degree discipline

Biology

Degree grantor

American University. College of Arts and Sciences

Degree level

  • Masters

Degree name

M.S. in Biology, American University, 2014

Local identifier

thesesdissertations_358_OBJ.pdf

Media type

application/pdf

Pagination

49 pages

Access statement

Electronic thesis available to American University authorized users only, per author's request.

Call number

Thesis 10128

MMS ID

99155820953604102

Submission ID

10658

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