American University
Browse
auislandora_93823_OBJ.pdf (3.79 MB)

Polymer modified carbon fiber microelectrodes for precision neurotransmitter metabolite measurements

Download (3.79 MB)
journal contribution
posted on 2023-08-05, 13:03 authored by Pauline Wonnenberg, Whirang ChoWhirang Cho, Favian A. Liu, Thomas Asrat, Alexander ZestosAlexander Zestos

Carbon fiber-microelectrodes (CFMEs) are considered to be one of the standard electrodes for neurotransmitter detection such as dopamine (DA). DA is physiologically important for many pharmacological and behavioral states, but is readily metabolized on a fast, subsecond timescale. Recently, DA metabolites such as 3-methoxytyramine (3-MT) and 3,4-dihydroxyphenylacetaldehyde (DOPAL) were found to be involved in physiological functions, such as movement control and progressive neuro degeneration. However, there is no current assay to detect and differentiate them from DA. In this study, we demonstrate the co-detection of similarly structured neurochemicals such as DA, 3-MT, and DOPAL. We accomplished this through electrodepositing CFMEs with polyethyleneimine (PEI) and poly(3,4-ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) polymers. This endowed the bare unmodified CFMEs with surface charge, physical, and chemical differences, which resulted in the improved sensitivity and selectivity of neurotransmitter detection. The differentiation and detection of 3-MT, DOPAL, and DA will potentially help further understand the important physiological roles that these dopaminergic metabolites play in vivo.

History

Publisher

Journal of the Electrochemical Society

Notes

Journal of the Electrochemical Society, Volume 167, Issue 16, December 2020, Article number 167507.

Handle

http://hdl.handle.net/1961/auislandora:93823

Usage metrics

    Chemistry

    Categories

    No categories selected

    Exports

    RefWorks
    BibTeX
    Ref. manager
    Endnote
    DataCite
    NLM
    DC