American University
auislandora_78207_OBJ.pdf (495.33 kB)

Cocaine cues retain silent traces of an excitatory history after conversion into conditioned inhibitors : 'the ghost in the addict' : The ghost in the addict

Download (495.33 kB)
journal contribution
posted on 2023-08-05, 11:23 authored by Stanley J. Weiss, David KearnsDavid Kearns

The present experiment investigated the extent to which the A+/AB- conditioned inhibition procedure could counteract an excitatory drug-related conditioning history. In two groups of rats, a light stimulus was established as a signal for the absence of cocaine. For the History group, the light had previously been a discriminative stimulus (S-D) that occasioned cocaine self-administration and could thus be classified as a cocaine excitor. In comparison, the No-History group first encountered the light during conditioned inhibition training. During conditioned inhibition training, both groups self-administered cocaine during tone as well as during click S(D)s, whereas drug seeking was eliminated in click-plus-light, wherein cocaine was not available (A+/AB-). Drug seeking was essentially eliminated in both groups. Nevertheless, on a summation test the light reduced cocaine seeking occasioned by the tone S-D by 95% in the No-History group, but by less than 50% in the History group. This summation test result showed that the effects of a drug-related history persisted even after the light was converted into an effective conditioned inhibitor on the training baseline through the powerful A+/AB- procedure. Future research should seek procedures that produce even stronger conditioned inhibition that eliminates such residual silent' drug excitation, the ghost in the addict'.



Behav Pharmacol


Usage metrics



    No categories selected


    Ref. manager